Pharmacology Clemastine

-






clemastine antihistamine anticholinergic , sedative effects. antihistamines competitively bind histamine receptor sites, reducing neurotransmitter s effects. effects of histamine (which countered antihistamines) include:



increased capillary permeability
increased capillary dilatation
edema (i.e., swelling)
pruritus (itch)
gastrointestinal/respiratory smooth muscle constriction

clemastine inhibits both vasoconstrictor , vasodilator effects of histamine. depending on dose, drug can produce paradoxical effects, including cns stimulation or depression.


most antihistamines exhibit type of anticholinergic activity. antihistamines act competitively binding h1-receptor sites, blocking binding endogenous histamine. antihistamines not chemically inactivate or prevent normal release of histamine.


clemastine act fiasma (functional inhibitor of acid sphingomyelinase).


clemastine rapidly absorbed gastrointestinal tract , peak plasma concentrations attained in 2–4 hours. antihistamines thought metabolized in liver, mono-/didemethylation , glucuronide conjugation. inhibitor of cytochrome p450 cyp2d6 , may interfere other drugs metabolized isozyme.








Comments

Post a Comment

Popular posts from this blog

History Alexandra College

-
alexandra college (on right) circa 1890 the school founded in 1866 , takes name princess alexandra of denmark, school s patron. school colours, red , white, adopted danish flag in honour. alexandra college founded anne jellicoe, quaker educationist, in name of furthering women s education. under anne jellicoe, school grew small establishment focused on providing governess-style education irish protestant ladies pioneering force women s rights , education, providing education women equivalent available in boys schools, grounding in mathematics, history, classics , philosophy. alexandra settled role, anne jellicoe convinced major obstacle liberal education of women exclusion university campus. passionately believed until women admitted trinity college dublin (founded in 1592), voice of women not commonly heard in politics, literature or in academic debate. the royal university of ireland act 1879 allowed females take university degrees on same basis males. students prepared examination...
Read more

Independence United Arab Emirates

-
historic photo depicting first hoisting of united arab emirates flag rulers of emirates @ union house, dubai on 2nd of december 1971. zayed bin sultan al nahyan first president of united arab emirates , recognized father of nation. by 1966, had become clear british government no longer afford administer , protect united arab emirates. british mps debated preparedness of royal navy defend sheikhdoms. secretary of state defence denis healey reported british armed forces overstretched , in respects dangerously under-equipped defend sheikhdoms. on 24 january 1968, british prime minister harold wilson announced government s decision, reaffirmed in march 1971 prime minister edward heath end treaty relationships 7 trucial sheikhdoms, had been, bahrain , qatar, under british protection. days after announcement, ruler of abu dhabi, sheikh zayed bin sultan al nahyan, fearing vulnerability, tried persuade british honour protection treaties offering pay full costs of keeping british armed forces i...
Read more